Perlane® is an injectable cosmetic dermal filler that has been used to soften wrinkles and facial folds of patients across the world. It is also a popular filler for lip augmentation, facial depressions, and facial scarring.

Perlane® is made from non-animal stabilized hyaluronic acid (NASHA) gel. This means that Perlane® contains no animal products. Since hyaluronic acid is a natural substance found in the skin and other tissue, there is no need for a skin test when using Perlane® filler.

The hyaluronic acid in Perlane® supplements the body's natural supply, which becomes depleted with age. Perlane® is biodegradable so its effects are not permanent. The results of a Perlane® filler treatment tend to last six months to a year. This is much longer than the typical results of collagen injections, which may only last three to six months.

Unlike BOTOX® Cosmetic, Perlane® does not make you numb. Perlane® can be used in conjunction with BOTOX® Cosmetic, which neutralizes the muscles that create wrinkles, but Perlane® simply reduces the visibility of wrinkles and folds.

Perlane® is primarily the same product as Restylane®, but Perlane® filler contains a larger concentration of hyaluronic acid. Because of this higher concentration of hyaluronic acid, Perlane® is usually used for larger folds, while Restylane® is better suited for smaller wrinkles or to maintain the results of a previous Perlane® injection.

We remain innovative injectors of the hyaluronic acids and not only published the first papers in the U.S. literature to instruct other physicians about these fillers, but we were also the practice that first identified the appropriate use of the enzyme hyaluronidase which can be used to immediately dissolve these fillers, if needed.